Early Menopause May Raise a Woman’s Odds for Dementia

TUESDAY, March 1, 2022 (HealthDay Information) — Women who enter menopause early might be a lot more very likely to develop dementia later on in existence, new exploration indicates.

During menopause, output of the feminine sex hormone estrogen drops substantially and a woman’s durations arrive to an finish. Though women typically enter menopause in their early 50s, quite a few do so previously — possibly naturally or due to a medical condition or procedure this kind of as a hysterectomy (elimination of the uterus).

This massive research discovered that women in the U.K. who entered menopause in advance of age 40 ended up 35% a lot more possible to create dementia later on in everyday living than gals who started out menopause all-around age 50.

What’s far more, gals who entered menopause just before age 45 have been 1.3 times more possible to develop dementia before their 65th birthday, the new research confirmed.

“Women with early menopause may perhaps want a near monitoring of their cognitive drop in scientific exercise,” reported examine writer Dr. Wenting Hao, a Ph.D. applicant at Shandong College in Jinan, China.

The higher hazard for dementia may well be because of to the sharp estrogen fall that normally takes put in the course of menopause, Hao stated.

“Estrogen can activate cellular anti-oxidants these kinds of as glutathione, minimize ApoE4, the most popular genetic danger issue in the pathogenesis of dementia, and lessen amyloid plaque deposition in the mind,” she spelled out.

The establish-up of amyloid plaques in the brain is a person of the hallmarks of Alzheimer’s disease, the most prevalent style of dementia.

This does not signify that gals who start off menopause early are powerless against dementia, Hao mentioned.

“Dementia can be prevented, and there are a selection of methods girls who practical experience early menopause may be able to decrease their risk of dementia,” he claimed. This incorporates obtaining normal physical exercise, collaborating in leisure and educational functions, not smoking or employing liquor, and retaining a healthy bodyweight, she claimed.

For the examine, scientists compared age at menopause and dementia diagnosis between 153,291 females (ordinary age: 60) who ended up part of the British isles Biobank, a big database of genetic and overall health info on persons dwelling in the United Kingdom. They looked for all sorts of dementia, including Alzheimer’s.

Postmenopausal girls are at increased possibility of stroke than pre-menopausal girls, and stroke may induce vascular dementia, but the research observed no url in between age at menopause and the chance of this form of dementia.

When females who entered menopause early were being at better possibility of dementia, individuals who entered menopause at age 52 or later on experienced comparable premiums of dementia as females who started out menopause at age 50 or 51, the review confirmed.

The new findings held right after researchers accounted for other components that may well strengthen dementia risk, which includes age at very last test, race, training, cigarette and alcohol use, human body fats, coronary heart ailment, diabetic issues, profits and leisure and actual physical actions. The study did not involve info on irrespective of whether gals experienced a family history of dementia or if ladies entered menopause early for pure or professional medical motives, which could have an affect on the conclusions.

The findings were presented Tuesday at a assembly of the American Heart Association held in Chicago and on-line. Exploration offered at medical conferences is generally considered preliminary right up until printed in a peer-reviewed journal.

These results are steady with other research displaying a bigger risk of dementia among the females with untimely or early menopause, said Dr. Stephanie Faubion, professional medical director of the North American Menopause Culture and director of the Mayo Clinic Center for Women’s Wellbeing.

“The early decline of estrogen is connected with an increased danger of multiple adverse extensive-time period well being outcomes, and dementia is just a single of them,” claimed Faubion. Other individuals incorporate heart condition, brittle bone sickness, osteoporosis, temper disorders, sexual dysfunction and early death.

There may perhaps be a purpose for hormone alternative therapy, she reported.

“In addition to suggesting checking of these ladies, replacing estrogen is a important system and has been proven to mitigate dementia hazard (and other dangers) in women with untimely or early menopause,” Faubion mentioned.

For decades, hormone replacement treatment was extensively recommended to handle signs of menopause and lower chance for heart ailment, osteoporosis and dementia. This all transformed when the landmark Women’s Overall health Initiative review confirmed that getting estrogen and progestin soon after menopause may possibly enhance women’s possibility for stroke, heart condition, blood clots and breast cancer. (Estrogen allows with menopause signs and symptoms like incredibly hot flashes and vaginal dryness, and progestin is included to defend from uterine cancer in women of all ages who nevertheless have a uterus.)

These days, hormone alternative treatment may be prescribed in the lowest dose for the shortest sum of time to maximize added benefits and minimize potential hazards.

Additional details

The Alzheimer’s Affiliation offers ideas on preventing dementia.


Resources: Wenting Hao, MD, PhD candidate, Shandong College, Jinan, China. Stephanie Faubion, MD, MBA, director, Heart for Women’s Well being, Mayo Clinic, Rochester, Minn., and Jacksonville, Fla., and professional medical director, North American Menopause Modern society March 1, 2022, presentation, American Coronary heart Association meeting, Chicago